I am happy to be a co-author on Liam Longo’s manuscript which has been accepted to the journal Cell: Structure!  The paper is titled, “Alternative Folding Nuclei Definitions Facilitate the Evolution of a Symmetric Protein Fold from a Smaller Peptide Motif.”

During this project, I helped Liam with expression and purification of some “circular permutations” of FGF-1 (a protein).  We discovered that circular permutation of FGF-1 is too destabilizing and none of the mutant proteins were able to fold.